The present work focused on the formulation and evaluation of transdermal patch of Diclofenac sodium using natural polymers. transdermal patch of Diclofenac sodium was prepared using different concentration of natural polymers like Prosopis seed gum and Gaur gum. Solvent evaporation technique was used to prepare the diclofenac sodium patch. Compatibility of the drug and the polymers was studied by infrared spectroscopy. Prepared transdermal patch were evaluated for thickness, weight variation, tensile strength, percent elongation, percent moisture content, moisture uptake, folding endurance and content uniformity test. The results obtained showed Compatibility between the drug and the polymers. The in vitro permeation study was carried out using Franz diffusion cell and egg membrane. The formulation followed the Higuchi diffusion mechanism. The formulation (P4) containing Prosopis seed gum 300 showed better sustain drug release diffusion as compaired Gaur gum formulation.
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